According to the modern view, levels of С-reactive protein, determined by high-sensitive method (hsСРБ), reflect slow inflammation in the vessel intima and prospectively assess the risk of cardio-vascular complications, adding to prognostic information, received from classical risk factors. The work presents data on hsСРБ base levels in healthy population and in patients with cardio-vascular diseases. Questions of hsСРБ diagnostic potential, methodical aspects and prospects of this test application in cardiology and practical health service are discussed.